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Beyond mitochondrial support, the reprogramming of amino acid metabolism breaks metabolic checkpoints to relieve the inhibition of exhausted T cells and potentiate immunotherapy [376]
Seiwerth, S., et al
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Treatment with acmopatide (CT-868), a dual glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptor agonist (GLP-1/GIP RA), improved glycemic management while reducing weight, insulin dose, and blood pressure in a phase 2 clinical trial of adults living with type 1 diabetes and obesity
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